Figure 1.
Cytogenetic abnormalities in IgM-MM. (A) Translocations in 15 patients with IgM MM. All 15 samples (each circos plot represents 1 patient) from newly diagnosed patients with IgM-MM had t(11;14) translocation (shown in red). Other translocations are shown with black links. Chromosomes from chr1 to chrY are ordered clockwise. (B) Patients with IgM (n = 15) displaying t(11;14) translocations involving predominantly DJ genes and deletions suggestive of VDJ recombination. Only 4 patients had deletions suggestive of class-switch recombination, and 6 had translocations involving class-switch regions. The IgH region is shown on the left side of the panel, and the CCND1 region is shown on the right side. IgH region genes and switch regions are color coded. Translocations (inner links) are also color coded by their classes. (C) Patients with IgG (n = 20) with t(11;14) translocations involving DJ genes and class-switch regions and deletions suggestive of VDJ recombination and class switch to IgG subtype. (D) Patients with IgA (n = 4) displaying t(11;14) translocations involving DJ genes and class-switch regions and deletions suggestive of VDJ recombination and class switch to IgA subtype. (E) WM samples (n = 55) displaying deletions suggestive of VDJ recombination, and 4 patients displaying class switching to IgG and IgA. None of the WM samples had translocation involving IgH region. (F) Copy-number alterations (CNA) in non–t(11;14)-MM samples (n = 165), non−IgM-t(11;14) samples (n = 36), IgM-MM samples (n = 15), and WM samples (n = 55). For each group gain (green) and deletion (red), frequencies are shown (y-axis). Regions that are statistically different between IgM-MM vs non−IgM-t(11;14)-MM or IgM-MM vs WM or both are color coded, and significant alterations are highlighted (P < .05). (G) Oncoplot of coding and noncoding mutations in MM driver genes for IgM (n = 15) and non−IgM-t(11;14) (n = 43) patients. Significant differences for coding mutations in each gene are marked with an asterisk on the left side and for noncoding mutations on the right side. Immunoglobulin type of each patient is shown at the bottom with color codes (green for IgM, orange for IgG, red for light chain only, blue for IgA, and turquoise for IgD). Mutation types are also shown in each cell with color codes explained at the bottom. IGL, immunoglobulin light chain; 3′UTR, 3′ untranslated region.

Cytogenetic abnormalities in IgM-MM. (A) Translocations in 15 patients with IgM MM. All 15 samples (each circos plot represents 1 patient) from newly diagnosed patients with IgM-MM had t(11;14) translocation (shown in red). Other translocations are shown with black links. Chromosomes from chr1 to chrY are ordered clockwise. (B) Patients with IgM (n = 15) displaying t(11;14) translocations involving predominantly DJ genes and deletions suggestive of VDJ recombination. Only 4 patients had deletions suggestive of class-switch recombination, and 6 had translocations involving class-switch regions. The IgH region is shown on the left side of the panel, and the CCND1 region is shown on the right side. IgH region genes and switch regions are color coded. Translocations (inner links) are also color coded by their classes. (C) Patients with IgG (n = 20) with t(11;14) translocations involving DJ genes and class-switch regions and deletions suggestive of VDJ recombination and class switch to IgG subtype. (D) Patients with IgA (n = 4) displaying t(11;14) translocations involving DJ genes and class-switch regions and deletions suggestive of VDJ recombination and class switch to IgA subtype. (E) WM samples (n = 55) displaying deletions suggestive of VDJ recombination, and 4 patients displaying class switching to IgG and IgA. None of the WM samples had translocation involving IgH region. (F) Copy-number alterations (CNA) in non–t(11;14)-MM samples (n = 165), non−IgM-t(11;14) samples (n = 36), IgM-MM samples (n = 15), and WM samples (n = 55). For each group gain (green) and deletion (red), frequencies are shown (y-axis). Regions that are statistically different between IgM-MM vs non−IgM-t(11;14)-MM or IgM-MM vs WM or both are color coded, and significant alterations are highlighted (P < .05). (G) Oncoplot of coding and noncoding mutations in MM driver genes for IgM (n = 15) and non−IgM-t(11;14) (n = 43) patients. Significant differences for coding mutations in each gene are marked with an asterisk on the left side and for noncoding mutations on the right side. Immunoglobulin type of each patient is shown at the bottom with color codes (green for IgM, orange for IgG, red for light chain only, blue for IgA, and turquoise for IgD). Mutation types are also shown in each cell with color codes explained at the bottom. IGL, immunoglobulin light chain; 3′UTR, 3′ untranslated region.

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