HLA class I allele loss. (A) Number of patients with HLA loss due to HLA gene mutations, 6p LOH, or both in a total of 412 subjects tested. (B) The number and proportion of patients who lacked individual HLA alleles (left); the total and mean number of clones with HLA gene mutations and 6p LOH among patients who lost respective HLA alleles (right). The number of patients tested for the presence of HLA loss is shown in parenthesis. (C) Combined clone size of cells with HLA loss (upper) and the clone size of individual HLA gene mutations and 6p LOH among cells with HLA loss (lower). (D) Positions and types of somatic inactivating mutations in HLA-A (n = 123) and HLA-B (n = 267). Hotspot mutations are noted on the figure.