The time-lapse snapshots of SIPA divided into 3 stages. (A-C) Stage 1: VWF elongation. The activation of VWF requires its conformational change from a globular state to an elongated state. (D-F) Stage 2: agglomeration. Elongated soluble VWFs entangle platelets and form platelet agglomerates in flow. (G-I) Stage 3: capture. Suspended agglomerates contact the thrombotic surface (preadhered with immobilized VWF), roll, and eventually adhere to the surface and become a mural platelet aggregate. (J) The number of GPIb-A1 bonds over time. The number of GPIb-A1 bonds shows faster growth at stage 2 (agglomeration) compared with stage 1 and stage 3. The specific simulation here is performed at a shear rate of 10 000 s⁻¹ with an sVWF concentration of 3 times normal plasma (NP)-VWF concentration and a VWF length of 1.6 $μ$m. The 3 times VWF concentration is selected to ensure 1 complete SIPA process would occur.