MondoA suppresses MYC targets including fatty acid metabolism, Oxphos, and ROS-pathway genes in B-ALL. (A) GSEA data summary represented as network generated using Cytoscape (version 3.7.1). Nodes depicted in the networks represent Hallmarks from GSEA with a false discovery rate (FDR) q-val < 0.05. Red color indicates negative normalized enrichment score (NES; overexpressed in MKD [REH, Nalm6, 697]) compared with control cell lines (REH, Nalm6, 697). Size of nodes corresponds to the number of genes in the pathway that belong to the core enrichment in gene set. Saturation intensity represents absolute NES. Edges connecting nodes represent number of genes that are shared between the 2 gene sets. (B) GSEA summary represented as network of Nalm6 cell lines either MKO or control Nalm6. Data representation as described in panel A. (C) Enrichment plots of significantly altered gene sets as yielded by the GSEA of microarray data of Nalm6 cell line with and without MKO. GSEA summary for MKO as well as GSEA summary for 3 cell lines (REH, Nalm6, 697) with knockdown in supplemental Figure 3C-D. Gene sets stimulated by MondoA according to MKD and MKO experiments are shown in supplemental Figure 3A-B. Heat maps showing representative genes comprising MYC-target, Oxphos, fatty acid metabolism, and glycolysis gene sets are shown in supplemental Figure 3E.