GSEA of RNA expression profiles of Utx^Δ/ΔLSKs. (A) GSEA plots of Utx^Δ/Δ vs Utx^+/+ LSKs. The results of the most positively enriched plot (Oxidative phosphorylation) and most negatively depleted plot (TGF beta signaling) in Utx^Δ/Δ LSKs are shown with normalized enrichment score (NES) and false discovery rate (FDR). (B) GSEA plots comparing differently expressed genes in Utx^Δ/Δ and Utx^+/+ LSKs and aging-associated genes in HSPCs.⁴⁷  The results of plots that increased with age (Aging Up Top200) and decreased with age (Aging Down Top200) are shown with NES and FDR. (C) GSEA plots comparing Utx^Δ/Δ LSK genes with HSPC and myeloid gene signatures. The results of comparison with 3 HSPC expression profiles (Armstrong Laboratory, Lemischka Laboratory, and Goodell Laboratory)^50-52  and with a myeloid expression profile (Goodell Laboratory)⁵²  are shown with NES and FDR.