Analysis of hematopoietic parameters and morphological changes in Utx-deficient mice. (A) Analysis of hematopoietic parameters in the PB (top), BM (middle), and spleen (bottom) of Utx^+/+, Utx^+/Δ, and Utx^Δ/Δ female mice. Hgb: hemoglobin concentration, Plt: platelet number. *P < .05; **P < .01; ***P < .001; comparison of Utx^+/+, Utx^+/Δ, and Utx^Δ/Δ mice, assessed with a 1-way analysis of variance followed by Tukey’s test. (B) Morphological changes of hematopoietic cells in the PB (panels 1-6) and BM (panels 7-10) of Utx^Δ/Δ mice. WBCs with abnormal nuclei (panels 1-3), including Pseudo Pelger-Huët anomalies (arrows) and hypersegmentation (arrowhead). A giant platelet (panel 4, arrowhead). An erythrocyte with a Howell-Jolly body (panel 5, arrow). Apoptotic cells (panel 6, arrows). Myeloid progenitor cells with abnormal nuclei and micromegakaryocytes (panels 7-10, arrows and arrowheads, respectively).