(A) Schematic representation of eQTLs identified in iPSC-derived MKs (n = 185) and platelets (n = 290) from healthy donors. Of eQTLs identified in MKs and platelets, 74.9% and 84.3%, respectively, were unique to tissue type. Three hundred twenty-three eGenes and 57 matching lead cis-eQTLs were in both MKs and platelets, and 6 map to GWAS identified platelet traits. (B) eQTLs are genetic variants, or differences in DNA between individuals (depicted by the A [blue] vs C [purple] nucleotides) that are associated with RNA abundance. eQTLs in both platelets and MKs were enriched in MK regulatory regions, such as enhancers linking differential regulation of transcription in MKs to RNA abundance carried over into platelets. These differences may in turn impact proteins, phenotypes, and function in health and disease.