Markov model for TITAN trial. Shown are the various health states possible for patients enrolled on the TITAN trial, which include the disease state (ie, active TTP necessitating treatment), the well state (no active TTP), and death. All patients in the clinical trial start in the disease state, with some transitioning to the well state and some transitioning to death. Patients in the well state who have a recurrence will return back to the disease state, at which point the cycle starts again.