Clinical impact of DLBCL microenvironment-based stratification model. (A) Schematic representation showing the scoring system used to calculate DMS score. (B) Kaplan-Meier DFS curve based on DMS score. (C-F) Mosaic plots showing correlation of DMS score with disease site and canonical prognostic models: (C) disease site (n = 170), (D) Hans criteria (n = 160), (E) Lymph2Cx (n = 170), (F) IPI score (n = 152). The correlation was calculated using the Fisher's exact test. DMS-low cases were enriched in ABC-type DLBCL, based on Lymph2Cx, and vice versa, but we observed no correlation with Hans criteria or IPI score. Shown are Kaplan-Meier DFS curves based on disease site, Hans criteria, Lymph2Cx (31 unclassified cases were excluded), and IPI in all cases and by DMS score in each subgroup. The DMS score had prognostic value in all subtypes, based on these classifications. A log-rank test was used for survival analysis.