American Society of Hematology

Figure 4.

Prediction of Gα coupling probabilities of GPR34 and its various mutants by the machine-learning program PRECOG (http://precog.russelllab.org).18 A value >0.5 indicates a high probability of G protein–coupling property and is highlighted in red. The proposed effectors/signaling pathway activations downstream of Gα and Gβγ are based on previous literature.12,25–27 WT, wild type.

Prediction of Gα coupling probabilities of GPR34 and its various mutants by the machine-learning program PRECOG (http://precog.russelllab.org).¹⁸ A value >0.5 indicates a high probability of G protein–coupling property and is highlighted in red. The proposed effectors/signaling pathway activations downstream of Gα and Gβγ are based on previous literature.^12,25–27 WT, wild type.

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