P_gen for TCRα and TCRβ clonotypes. Shared TCRα^aa and TCRβ^aa clonotypes were identified using the Immunarch pipeline and their P_gen was calculated using the OLGA algorithm (Figure 1) from DNA and RNA data. (A) P_gen histogram for the shared TCRα^DNA and TCRβ^DNA clonotypes. As a comparison, the P_gen values for the TCRβ^DNA clonotypes for the healthy control group are plotted. (B) Analogous histogram (as in panel A) showing P_gen for the shared clonotypes in TCRα^RNA and TCRβ^RNA.