Vβ and Jβ (TRBV/TRBJ) usage in TCLs. The identified TCRβ^DNA and TCRβ^RNA clonotypes from WES, WGS, and WTS data for the TCL diagnoses and control blood lymphocytes to identify preferential TRBV and TRBJ segment usage. (A-B) TRBV and TRBJ frequencies, respectively, in the 10 most abundant clonotypes. (C-D) Plots similar to those in panels A and B with the inclusion of the single most abundant clonotype. The control group is absent in panels C and D because of the lack of a high-frequency clonotype in these samples.