Summary of the methodological approach to TCR analysis in TCLs. The pie chart represents the percentage of sequencing samples collected from different subtypes of TCLs that were analyzed for TCF and the TCR clonotypes. Details for the diagnostic groupings are provided in supplemental Table 2. TCF was estimated on the basis of the chromosomal aberration identified using TitanCNA or IchorCNA. TCR clonotypes were identified using MiXCR. The diversity index (inverse Simpson), clonotype sharing (Jaccard index), and probability of clonotype generation (P_gen) were analyzed using Immunarch and OLGA pipelines, as described in “Methods.” SPTL, subcutaneous panniculitic TCL.