Genome-wide associations with platelet reactivity. Manhattan plot showing the P values of tests for association between genetic variants and each of 4 phenotypes measuring the reactivity of platelets to agonism by ADP, CRP-XL, PAR-1, and PAR-4 in the Cambridge PFC. Each dot corresponds to a genetic variant in the Haplotype Reference Consortium r1.1 reference panel. The position on the x-axis indicates the physical position of the variant; the position on the y-axis indicates the -log₁₀P value of a Wald test for association from a linear mixed-model (on a log scale). Only variants with an imputation INFO score > 0.6 and a P value < .1 are shown. The horizontal dashed line corresponds to the genome-wide significance threshold (5 × 10⁻⁸). The red dots correspond to the variants showing the strongest evidence for association in those loci containing significantly associated variants. The red gene names indicate the gene causally mediating each of these associations.