KDM5A KO led to the elevation of H3K4me2 of KDM5A target genes. (A) Pie chart showing the genomic distribution of KDM5A ChIP-seq peaks, annotated by using HOMER. The numbers represent the peak number in each category. (B) Heatmap analysis of the ChIP-seq profiles of KDM5A in NB4 and H3K4me2 and H3K4me3 in the control (Ctrl) and KDM5A-KO NB4 cells at KDM5A bound genes. Gene bodies ± 10 kb are shown, sorted by the intensity of KDM5A binding at promoter regions. (C) ChIP-seq signal density plots showing the global levels of H3K4me3 and H3K4me2 at KDM5A bound genes ± 10 kb. TES, transcription end site; TSS, transcription start site.