Genomic profiling of somatic mutations in baseline samples by NGS (comutation plot). Each column represents 1 patient (n = 202), and the rows represent different somatic mutations. The VAF for each phenotypic driver mutation is color coded. The frequency of specific somatic mutations is listed on the right border of the figure. Somatic mutations in 34 different genes were detected in 191 (95%) patients, including 92% with MPN phenotypic driver mutations: JAK2, 74%; CALR, 14%; or MPL, 5%. JAK2-UPD was observed in 28% and was significantly associated with PV (Kruskal-Wallis test, P < .0001). The most frequent concomitant mutations affected 3 genes: TET2 (24%), DNMT3A (16%), and ASXL1 (10%). 9p-UPD, uniparental disomy of chromosome 9p.