ERp46 but not other PDIs recover aggregation and ATP release of ERp46-null platelets. (A) ERp46-null platelets were incubated with 100 nM PDI, ERp57, ERp72, or ERp46. (B) PDI-null platelets were incubated with 100 nM ERp46 or PDI. (C) ERp57-null platelets were incubated with 100 nM ERp46 or ERp57. Platelet aggregation was stimulated with thrombin (0.015 U/mL); representative aggregation and ATP release tracings (left panel) and combined results (right); mean ± SEM, n = 3 (A); n = 5 (B); n = 3 (C); **P < .01, ***P < .001, ****P < .0001, ANOVA.