CC-92480, a cereblon (CRBN) E3 ligase-modulating drug (CELMoD), overcomes IMiD resistance in T-cell lymphomas. IMiD-resistant T-cell lymphomas show crucial co-dependence of IKZF1 and ZFP91 transcription factors. Binding of CC-92480 to CRBN leads to selective and potent degradation of IKZF1 and ZFP91, overcoming IMiD resistance in multiple subtypes of T-cell lymphoma. Ub, ubiquitin.

CC-92480, a cereblon (CRBN) E3 ligase-modulating drug (CELMoD), overcomes IMiD resistance in T-cell lymphomas. IMiD-resistant T-cell lymphomas show crucial co-dependence of IKZF1 and ZFP91 transcription factors. Binding of CC-92480 to CRBN leads to selective and potent degradation of IKZF1 and ZFP91, overcoming IMiD resistance in multiple subtypes of T-cell lymphoma. Ub, ubiquitin.

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