Event-free survival (modified GRFS). Events include death from any cause, GF, acute GVHD grade III to IV, extensive, moderate/severe chronic GVHD, and secondary procedure (DLI, boost, second HSCT, and splenectomy). Modified GRFS of the entire cohort (A), depending on the regimen used (B), donor type (C), period of HSCT (D), and age at HSCT (E). (F) Continuous hazard ratio depending on age at HSCT. Shaded areas represent the 95% confidence interval. MMFD, mismatched family donor; MMUD, mismatched unrelated donor; MFD, matched family donor; MSD, matched sibling donor; MUD, matched unrelated donor; TT, thiotepa; Tx, transplant.