Cellular kinetics after CAR T-cell infusion in groups stratified by cumulative fludarabine AUC_T0−∞ of 14 mg*h/L. (A) The AUCs of CAR T-cell numbers from the first 28 days after CAR T-cell infusion. The high and low fludarabine exposure groups consisted of 9 and 7 patients, respectively. Groups were compared using the Mann-Whitney U test. (B) LOESS regression curves of CD4+ T-cell recovery within the first month after CAR T-cell infusion in the whole cohort. (C) LOESS regression curves of CD8+ T-cell recovery within the first month after CAR T-cell infusion in the whole cohort. Groups were compared with linear mixed effect models. P < .05 considered statistically significant.