Malignancy amplifies the negative effect of obesity on insulin sensitivity. (A) Clamp-derived M in controls and patients with hematologic malignancies. (B) Clamp-derived whole-body ISI in controls and patients with hematologic malignancies. (C) Linear relationship between BMI and M across the study groups. (D) Linear relationship between BMI and clamp-derived ISI across the study groups. (C-D) Red and blue lines depict results for malignancy and control cohorts, respectively. Decreasing M and ISI values indicate lower insulin sensitivity and impaired glucose disposal.