Figure 2.
MARs are characterized by macrophage and CD8 T-cell infiltration with a peculiar histologic and gene expression pattern. (A) Clinical picture of a representative patient with MAR. (B) Histopathology of a lesional biopsy specimen of MAR. Magnification ×200; hematoxylin-eosin stain. Granulomatous infiltrate of the upper and mid dermis. (C) Immunohistochemistry (CD3, CD4, CD8, and CD163) on a lesional skin biopsy specimen of MAR. Magnification ×200.The infiltrate comprises macrophages (CD163) and a predominance of CD8 T cells, including intraepidermal CD8 T cells. (D) Histograms of T cell, CD8 T cell, macrophage, and monocyte mean percentages in skin at baseline, first rash, and second rash. (E) Histograms of cell populations: mean percentages in skin at baseline, first rash, and second rash. (F) Venn diagrams of differentially expressed genes (DEG) in MARs compared with MPRs and AGEP.

MARs are characterized by macrophage and CD8 T-cell infiltration with a peculiar histologic and gene expression pattern. (A) Clinical picture of a representative patient with MAR. (B) Histopathology of a lesional biopsy specimen of MAR. Magnification ×200; hematoxylin-eosin stain. Granulomatous infiltrate of the upper and mid dermis. (C) Immunohistochemistry (CD3, CD4, CD8, and CD163) on a lesional skin biopsy specimen of MAR. Magnification ×200.The infiltrate comprises macrophages (CD163) and a predominance of CD8 T cells, including intraepidermal CD8 T cells. (D) Histograms of T cell, CD8 T cell, macrophage, and monocyte mean percentages in skin at baseline, first rash, and second rash. (E) Histograms of cell populations: mean percentages in skin at baseline, first rash, and second rash. (F) Venn diagrams of differentially expressed genes (DEG) in MARs compared with MPRs and AGEP.

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