Putative basal oxidative stress (central stars) and effects of acute and regular physical exercise of different intensities on oxidative stress in patients with SCD with SOD2^WT or homozygous to the SOD2^V16A variant. The intensity of color (central stars) indicates the basal level of oxidative stress. Sizes of arrows indicate the putative size effect. Green and red colors indicate putative positive/blunting or negative/aggravating effects, respectively.