SS class characterization in skin biopsies. (A) Heat map of the PD-1 intensity of expression according to the 3 different phenotypic profiles. Each row corresponds to an intensity and percentage of patients among each SS class who show this intensity. Patient distribution among PD-1 intensity is significantly different in the CD158k⁻PD-1 class compared with the 2 other classes (χ² test, P = .024). (B) Heat map related to the morphology of the skin infiltrate. Each row corresponds to a morphologic characteristic and percentage of patients among each SS class who show this characteristic. (C) Heat map related to the cellular environment. It represents the percentage of patients within each SS class for which the presence of different cell types is observed (Fisher exact test). (D) Skin biopsies of different patients with SS showing difference of expression between the 3 phenotypic classes for CD20, CD8, and PD-1. From left to right and top to bottom: CD158k⁺ profile, CD20 (patient 20T45075, ×6.3); CD158k⁻PD-1⁺ profile, CD20 (patient 16T32744, ×6.2); CD158k⁻PD-1⁻ profile, CD20 (patient 16T844, ×7.9); CD158k⁺ profile, CD8 (patient 17t026310, ×7.5); CD158k⁻PD-1⁺ profile, CD8 (patient 16T28107, ×6.3); CD158k⁻PD-1⁻ profile, CD8 (patient 16T844, ×7.1); CD158k⁺ profile, PD-1 (patient 17T026310, ×6.3); CD158k⁻PD-1⁺ profile, PD-1 (patient 16T28107, ×5.8); CD158k⁻PD-1⁻ profile, PD-1 (patient 16T844PD1, ×5.3). Int, intermediate.