Clonality assessment of T cells by FC. Patients with SS were screened for TCRVβ repertoire restriction by FC. Each frozen FlowSOM of a patient with SS is represented next to the repartition of its TCRVβ repertoire and the 5 subsets of interest (% of lymphocytes). (A) Patients with SS with a CD158k⁺ profile (predominantly subsets 1 or 2, n = 9). (B) Patients with SS with a CD158k⁻PD-1⁻ profile (predominantly subsets 3 or 5; n = 5). (C) Patients with SS with a CD158k⁻PD-1⁺ profile (predominantly subset 4; n = 4).