SS subsets of interest. (A) Heat map of subset distribution (% of lymphocytes) in patients with SS (n = 18) and non-CTCL patients (n = 35). Each row corresponds to a subset of lymphocytes. Subset distribution is different between patients with SS and non-CTCL patients (2-way ANOVA; P < .0001). Five subsets (red box) are significantly overrepresented in patients with SS (Sidak’s multiple comparison test). (B) Subset distribution in each patient with SS. Each row corresponds to 1 patient with SS and shows the proportion of each subset of interest (% CD4⁺CD26⁻). Three SS classes were defined by the type of majority subset: blue font corresponds to CD158k⁺ SS (majority of 1 or 2); red corresponds to CD158k⁻PD-1⁺ SS (majority of 4), and black corresponds to CD158k⁻PD-1⁻ SS (majority of 3 or 5).