Figure 2.
Type I (not type II or III) IFN signaling is required for microbiome-mediated hematopoiesis. (A) LSK populations from mice with or without type I (Ifnar1−/−), type II (Ifngr1−/−), or type III (Ifnlr1−/−) IFN signaling after 2 weeks with or without VNAM (B) were quantified. (C) LSK populations were quantified from mice with or without type I IFN signaling in Vav-Cre;Ifnar1fl/fl mice after 2 weeks with or without VNAM according to flow cytometry. Results are compiled from 2 independent experiments (n = 7-11 per group; panels A and B) or from 3 independent experiments (n = 6-7; panel C). Graphs show mean ± SEM, with statistical significance determined by two-way analysis of variance with Šidák’s multiple comparisons test. **P < .01, ***P < .001, ****P < .0001. n.s., not significant.

Type I (not type II or III) IFN signaling is required for microbiome-mediated hematopoiesis. (A) LSK populations from mice with or without type I (Ifnar1−/−), type II (Ifngr1−/−), or type III (Ifnlr1−/−) IFN signaling after 2 weeks with or without VNAM (B) were quantified. (C) LSK populations were quantified from mice with or without type I IFN signaling in Vav-Cre;Ifnar1fl/fl mice after 2 weeks with or without VNAM according to flow cytometry. Results are compiled from 2 independent experiments (n = 7-11 per group; panels A and B) or from 3 independent experiments (n = 6-7; panel C). Graphs show mean ± SEM, with statistical significance determined by two-way analysis of variance with Šidák’s multiple comparisons test. **P < .01, ***P < .001, ****P < .0001. n.s., not significant.

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