CN profile of VRL. (A) Global CN (top) and CNN-LOH (bottom) profile of 6 VRL cases. The x-axis depicts chromosome positions with dotted lines indicating centromeres. The y-axis indicates the frequency of the genomic aberration among the analyzed cases. Each probe is aligned from chromosomes 1 to 22 and p to q. Gains are depicted in blue; losses are depicted in red, and regions of CNN-LOH are represented in mustard. Recurrent CN and CNN-LOH regions are indicated. (B) CDKN2A CN analysis of 12 VRL cases and reactive control samples. A CDKN2A CN assay was performed on 12 VRL cases (including TaqMan and OncoScan data) and 5 samples from reactive VBA cases in comparison. Data were analyzed according to the 2^-ΔΔCp method. Results are depicted as CNs relative to mean levels of reactive VBA (CN status, 1). Blue and red lines indicate wild-type CN status (1) and heterozygous deletion (0.5), respectively. A CN status of 0 indicates homozygous deletion. Statistical analysis was performed with the Mann-Whitney test. *P > .05.