Mutation distribution and number in mutated genes. (A) Schematic presentation of the most important mutated genes in VRL. Relative positions of mutations are shown for CD79B, ETV6, MYD88, PIM1, and TBL1XR1. The approximate location of somatic mutations identified in each gene is indicated. Domains of the protein are represented according to the Uniprot database (www.uniprot.org). (B) Analysis of mutation numbers per gene per sample. Red lines indicate the median number of mutations per gene. Genes in the frame are known targets of aSHM.