Cytological features of VRL: case 3. (A) The cytospin shows a cellular vitreous aspirate with large, atypical cells with irregular nuclei, frequent prominent nucleoli, and basophilic cytoplasm containing vacuoles admixed with small lymphocytes. Degenerative changes with frequent cell shadows are evident. May Grunwald-Giemsa stain, original magnification ×400. (B) CD20 staining of many atypical cells. The negative cells are likely to be T cells, macrophages (arrow), or degenerated tumor cells lacking preserved membrane staining. Immunoperoxidase; original magnification ×400.