Evolution of maximum daily body temperature, CRP, and SARS-CoV-2 viral load, before and after treatment with nmAbs. Evolution of temperature (A) and C-reactive protein (B) in each patient from 2 days before (day −2) to 5 days after (day 5) nmAb treatment (day 0). SARS-CoV-2 RNA was determined by quantitative RT-PCR, and cycle threshold values were translated to viral concentrations based on the respective PCR core standards. Viral loads obtained from respiratory tract specimens (C) and blood (D) before and after nmAb treatment are presented cumulatively and represent samples that were taken from 2 days before until midday at the day of nmAb treatment (pre-treatment) or from days 1 to 5 after treatment (post-treatment). If several samples were taken during these time periods the median from all available assessments is shown for each patient. Patient F is not included in panel C, as only samples obtained from BAL were positive and no subsequent assessments were performed. CRP, C-reactive protein; FU, follow-up; ND, not detected.