Treatment schema. Participants were initially treated with VEN, starting at 20 mg by mouth daily and increasing to 50 mg by mouth daily and 100 mg by mouth daily over 2 weeks (cycle 0*). Participants must have had at least 2 but no more than 4 days of 20 mg, and 3 but no more than 5 days of 50 mg before moving to 100 mg by mouth daily for 7 days. Ibrutinib (IBR), at the allocated dose, was added to venetoclax (VEN) at 100 mg by mouth daily for an additional 7 days (cycle 1, week 1). Weekly VEN dose titration was continued to the allocated dose as shown.