Outcome variables by DLCOcSB > or ≤60% of predicted in patients conditioned with high-dose melphalan prior to auto-HSCT. Kaplan-Meier curves represent OS (A) and PFS (B), and the cumulative incidence curve represent NRM (C) and relapse (D) incidence in patients with impaired lung function, as defined by DLCOcSB > 60% or ≤60% of predicted. Statistical analysis of OS and PFS was performed using the log-rank test, whereas that for the cumulative incidence of NRM and relapse was performed using Fine and Gray regression models in the presence of competing risks. HRs and SHRs represent the risk of DLCOcSB ≤ 60% of predicted compared with DLCOcSB > 60% of predicted. DLCOcSB values before auto-HSCT and prior to conditioning with high-dose melphalan were not available for 18 patients (6.1%). Pts., patients.