C-occurring somatic mutations in 53 patients with 50 unique P/LP variant(s). (A) Co-occurring somatic mutations for the patients with P/LP germline variants as determined by clinical panel and whole-exome sequencing. (B-E) Pedigree of 4 families with history of hematological malignancies and a P/LP germline variant identified in the genes TERT, MPL, DNAJC21, and CHEK2 in the proband, respectively. The number designated by “dx.” indicates the age at diagnosis, and that by “d.” indicates the age of death. The age at diagnosis or death is unknown for individuals if not indicated in the pedigree.