Germline screening for HM-predisposition variants in the Beat AML cohort identified 13.6% of patients with AML with P/LP variants classified according to American College of Medical Genetics and Genomics guidelines. Family history was also assessed independent of genomic findings, with 15% of assessed individuals positive for a family history of HMs. LP, likely pathogenic; NA, patients without variants in the other categories; P, pathogenic; pts, patients; VUS, variant of uncertain significance.