Outcomes of patients with mutations in the N-SH2 domain of the PTPN11 gene vs mutations in the PTP domain. (A) DFS based on the presence of an N-SH2 domain (blue line) or PTP domain (red line) PTPN11 mutation. (B) OS for patients with an N-SH2 domain (blue line) or PTP domain (red line) PTPN11 mutation. (C) EFS based on the presence of an N-SH2 domain (blue line) or PTP domain (red line) PTPN11 mutation.