Biological attributes of the molecular clusters. (A) Barplot showing differential gene expression signature enrichment between NNK and DMT cluster. Statistical significance was determined using pairwise Student t tests on scaled activity score values and was <0.05 for all the gene sets (NF-κB noncanonical activated, P = .004; NOTCH2 signaling, P = .043; apoptosis, P = .009; p53 signaling, P = .028; B-cell proliferation, P = .014; IL6/JAK/STAT3 signaling, P = .003). (B) The heatmap shows the distribution of TMA markers in NNK and DMT molecular clusters. A red color indicates the positivity of the marker, a white color indicates the negativity of the marker, and gray color indicates missing data. The barplot on the left shows the -log₁₀P value of a 1-sided Fisher’s exact test between the 2 clusters for each marker. (C) TP53, NOTCH2, and p50 expression in TMA cores from SMZL spleen sections.