Pathway-driven clustering of SMZL mutations. (A) Heatmap showing SMZL mutations collapsed into pathways and clustered using HCPC in the SMZL cohort. (B) Heatmap showing genes entering the clustering analysis. The genes are color-coded according to the assigned cluster and ordered according to the relative enrichment in the specific cluster represented as a bar on the right. Only genes with mutation rate >0.01 are shown. (C) The heatmap shows the enrichment of IGHV mutational status and recurrent CNA in the molecular clusters. Size and color intensities of the circles are proportional to the prevalence of each variable in the molecular cluster. The asterisk shows statistical significant differences (Fisher’s exact test P < .05).