Adjusted multivariable analysis by cytogenetic group. (A) Curves of the CIF for the outcome of relapse, showing the highest risk of relapse was among patients with adverse risk. KMT2A-rearranged patients also had an increased risk of relapse after 12 months. (B) Curves of the CIF for the outcome of NRM, showing no significant difference among the intermediate-risk, adverse-risk, or KMT2A-rearranged groups. (C) Kaplan-Meier curves for the outcome of LFS, demonstrating that patients with KMT2A rearrangements did worse than those with intermediate risk but similarly to patients with adverse risk. (D) Kaplan-Meier curves for the outcome of OS, where the KMT2A-rearranged group’s survival closely approximated that of the adverse-risk group.