Multivariable analyses. (A) The outcome of relapse, with the main effect of cytogenetic category and including the listed covariates. The HR for relapse among those with KMT2A rearrangement was 1.27, and among those with adverse risk was 1.71. (B) The outcome of NRM, with the main effect of cytogenetic category and including the listed covariates. The HR for NRM was not significantly different among the groups. (C) The outcome of LFS, with the main effect of cytogenetic category and including the listed covariates. The HR among those with KMT2A rearrangement was 1.26, and among patients with adverse risk was 1.47. (D) The outcome of OS, with the main effect of cytogenetic category and including the listed covariates. The HR for death among those with KMT2A rearrangement was 1.32 and among patients with adverse risk was 1.45.