Comprehensive heatmap of molecular profiling findings by RNA-seq of 173 patients with ALL enrolled on DFCI 16-001. RNA-seq data from 173 patients with ALL are summarized in this heatmap. Patients were classified on the basis of their respective clustering analysis subtype, gene fusions, and somatic mutations. Specific gene fusions and mutational categories are indicated by colored squares and classified by associated gene signaling pathways. Mutation types included single nucleotide variants, indels, and intragenic IKZF1 deletion (IK6). iAMP21, intrachromosomal amplification of chromosome 21; NA, not applicable; TCR-R, T cell receptor rearrangement; VUS, variant of unknown significance.