EFS and OS in patients older than age 65 years in the 2 different eras. EFS of patients older than age 65 years (A), (C) who received R-CHOP/R-CHOP-like or R-bendamustine (C), and who received nonstandard systemic therapy or nonsystemic therapy in Era 1 vs Era 2 (E). OS of patients older than age 65 years (B), who received R-CHOP/R-CHOP-like or R-bendamustine (D), and who received nonstandard systemic therapy or nonsystemic therapy in Era 1 vs Era 2 (F).