EFS and OS in patients age 65 years or younger in 2 different eras. EFS of patients age 65 years or younger (A), who received standard immunochemotherapy (C), and who received nonstandard systemic therapy or nonsystemic therapy in Era 1 vs Era 2. OS of patients (E) age 65 or younger (B), who received standard immunochemotherapy (D), and who received nonstandard systemic therapy or nonsystemic therapy in Era 1 vs Era 2 (F).