Latency types after EBV infection range from latency III to latency I/0. Latency III expresses all EBV-encoded proteins and is the most immunogenic, with expression of the immunodominant EBNA3 antigens. Latency II is less immunogenic, expressing only EBNA1, with 2 EBERs and LMP1 and LMP2. Latency III tumors are most amenable to adoptive cellular therapy, although LMP-specific T cells have also shown efficacy for latency II tumors. DLBCL, diffuse large B-cell lymphoma.