OHI-adapted HLH and hematologic malignancy (HM) workup. Early ordering of serum sCD25 and ferritin directs further testing and allows for adequate HLH control in OHI+ patients by concomitant immunosuppression before onset of end-organ damage.5 It also affects selection of diagnostic procedures aimed at exposing occult malignancies through adapted invasive multiorgan biopsies.3 dx, diagnosis; FHL, familial HLH.