Mutation profile and outcome in accelerated-phase myelofibrosis. (A) Waterfall plot on mutation pattern in 35 patients with accelerated-phase myelofibrosis, of whom 3 patients showed no detectable mutation. (B) Percentage of patients with detected mutation in accelerated-phase (N = 32) and chronic-phase myelofibrosis (N = 307) for a panel of 19 sequenced genes.