Outcome (OS, EFS, CIR) of the entire cohort and in each ELN risk category: (A) OS and EFS of the entire cohort. (B) OS according to ELN 2017 risk category. (C) EFS according to ELN 2017 risk category. (D-F) CIR and death without relapse of patients allocated in the ELN 2017 favorable (D), intermediate (E), and adverse (F) risk category. Pairwise comparison of OS, EFS, and CI has been adjusted with the Bonferroni method.