Distinct clusters identified based on genetic profiles throughout the spectrum of clinical phenotypes. (A) Mutation profiles of clusters identified by unsupervised clustering analysis based on genetic profiles throughout the spectrum of clinical phenotypes: CH-like cluster (left) and MN-like cluster (right). (B) Distribution of VAFs of mutation patterns in the 2 clusters identified by the unsupervised clustering analysis (CH-like cluster, blue curve; MN-like cluster, red curve). (C) Overall survival of the 2 clusters identified by the unsupervised clustering analysis (CH-like cluster, blue curve; MN-like cluster, red curve) and of individuals with no mutations (green curve). (D) Cumulative incidence of progression to MN estimated with a competing-risk approach within the CCUS cohort segregated based on unsupervised analysis (CH-like cluster, blue curve; MN-like cluster, red curve).