Distribution of mutation patterns in the cohorts included in the study. (A) Distribution of genotype complexity according to the number of mutations per subject in individuals with CHIP; unexplained anemia; CH-AoE, CCUS, and MN. (B) Distribution of distinct mutation patterns in individuals with CHIP, CH-AoE, CCUS, and MN. For this purpose, genotypes were cataloged based on gene ontology classification involving DTA, splicing factors, TP53, and other drivers. Distributions were calculated as proportions of the total number of cases with the genotype under consideration, to provide a measure of the relative frequency by which the same genotype may exhibit different clinical phenotypes.