Mutational profile of primary AML cells with germline RUNX1^mut shows enrichment of activated signaling pathway. (A) Mutation grid of RUNX1-mutated primary AML specimens showing 1 patient sample per column. Samples are grouped according to their RUNX1 mutation germinal status. Co-occurring mutated genes are shown in each row and are grouped by gene ontology. Enrichment between comparison groups was calculated using the Fisher’s exact test. Distribution of the most frequent mutated genes (B) and mutated groups (C) in germline and somatic RUNX1 patient cohorts. TF, transcription factor.